J.Jpn. Surg. Soc.. 94(8): 824-831, 1993

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Original article

HEMODYNAMIC CHANGES IN ACUTE PANCREATITIS

Hemodynamic studies were carried out from days 1-5 following the onset of illness in 7 patients with severe pancreatitis (group A) and in 7 patients with moderate pancreatitis (group B). Patients in both groups had a higher cardiac index (Cl) and a lower systemic vascular resistance (SVR) than normal patients during 5 days of illness, and patients in group A had a higher CI of 5.38±0.841・min/m² and lower SVR of 889±234dyn・sec/cm⁵ than those in group B on day 4. Patients in group A had a lower pulmonary vascular resistance than normal patients on days 1, 3, and 4, but those in group B did not show this hemodynamic change. Group A patients had a higher pulmonary wedge pressure of 11.9±8.4mmHg and depressed left ventricular stroke work index of 59.8±17.8g・m/m² as compared with group B (5.6±3.4mmHg, 77.7±23.6g・/m², respectively). These findings indicate that a hyperdynamic hemodynamic state may exist in the early stages of moderate and severe pancreatitis and myocardialdepression may be evident in severe pancreatitis.

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