J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 846KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 94(3): 225-233, 1993

Original article

ROLE OF OXYGEN RADICALS IN THE PATHOGENESIS OF ACUTE GASTRIC MUCOSAL LESION UNDER OBSTRUCTIVE JAUNDICE

1) The First Department of Surgery, School of Medicine, Iwate Medical University, Morioka, Japan
2) Department of Biochemisty, School of Medicine, Iwate Medical University, Morioka, Japan

Hironobu Ito1,2), Hiroshi Asahi1), Saburo Horiuchi2)

In this study we examined the role of oxygen-derived free radicals in the pathogenesis of acute gastric mucosal lesion induced by obstructive jaundice in rats. Rats were divided into 4 groups as foUows : control (sham operation), jaundiced (ligation and dissection of bile duct), vagotomized (truncal vagotomy), and vagotomized with jaundice group. The water immersion restraint procedure was performed. The water immersion restraint procedure was performed. The results obtained are as follows : jaundiced group showed significant increase of ulcer index (UI) and significant decrease of gastric mucosal blood flow (GMBF) and gastric mucosal potential difference (PD).
However, intragastric pH (pH) was unchanged compared to the control group．Oxygen radical generating system (gastric mucosal XOD activity and thiobarbiturate acid) and oxygen radical scavenging system (gastric mucosal SOD activity and GSH-px activity) were higher than those of control group. Vagotomized group showed significant increase of pH compared to the control group. Oxygen generating system and scavenging system were unchanged compared to the control group. Vagotomized with jaundice group showed depression of UI and improvement of oxygen radical generating system and scavenging system. However GMBF, PD nad pH were unchanged compared to the jaundiced group. These results suggest that oxygen radical play some role in the development of acute gastric mucosal lesion induced by obstructive jaundice.

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