[
Abstract]
[
Full Text PDF] （in Japanese / 2539KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 94(1): 21-26, 1993
Original article
EXPRESSION OF THE BLOOD GROUP RELATED ANTIGENS（LEWISa, LEWISb, LEWISx, LEWISy), AND OTHER GASTROENTEROLOGICAL TISSUE RELATED ANTIGENS（CEA, APF, AND NSE） IN POORLY DIFFERENCIATED ADENOCARCINOMA OF GASTRIC CANCER WITH MEDULLARY GROWTH PATTERN
To clalify the clinico-pathological characteristic of poorly differentiated adenocarcinoma of gastric cancer with medullary growth pattern, the immunohistochemical study was performed using antlbodies against blood group related antigens (Lewis
a, Lewis
b, Lewis
x, Lewis
y) and gastrointestinal tissue related antigens (CEA, AFP and NSE). The following results were obtained. 1. Foveolar epithelium of normal gastric mucosa has type 1 blood group associated antigen (Lewis
a, Lewis
b) and deep gland has type 2 antigen (Lewis
x, Lewis
y) respectively, as the differentiation antigens. 2. Expression of Lewis
a and Lewis
b are more often observed in poorly differentiated adenocarcinoma with medullaly and scirrhous growth pattern than in well and moderately differentiated adenocarcinoma. Poorly differentiated adenocarcinomais postulated to have closer relation with normal gastric deep gland in terms of antigen expressin. 3. Poorly differentiated adenocarcinoma with medullaly growth pattern is characterized as more differentiated type cancer than scirrhous type with respect to expression of blood group related antigen. 4. Poorly diffferentiated adenocarcinoma with medullaly growth pattern may be divided into 3 subgroups by each antigen expression of CEA, NSE, and AFP.
To read the PDF file you will need Adobe Reader installed on your computer.