J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2509KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 93(6): 589-598, 1992

Original article

EXPERIMENTAL STUDIES ON THE EFFECTS OF α-TOCOPHEROL IN SMALL INTESTINAL ISCHEMIA AND REPERFUSION INJURY 　

Department of Surgery, Fujita Gakuen Health University School of Medicine, Toyoake, Japan

Gento Hanai, Tadahiro Kimura, Tenzo Shiraishi, Makoto Sano, Sumio Matsumoto, Takahiko Funabiki, Satoshi Yoshizaki

In the present study, we quantified the biochemical［thiobarbituric acid（TBA）reactants, superoxide dismutase （SOD）and vitamine E］and histologic changes in the small intestinal tissue after ischemia and/or reperfusion.
Sixty-seven Wistar rats were divided into 7 groups；N group：control, A-I group：30 min. ischemia, A-II group： 120 min. ischemia, B-I group：Declamp after 30 min. ischemia, B-II group：30 min. reperfusion after 30 min. ischemia, B-III group：30 min. reperfusion after 120 min. ischemia, E group：vitamine E administration 30 min. reperfusion after 30 min. ischemia.
The levels of TBA reactants were significantly different between A-II and B-II, B-II and E（all p＜0.01）. For SOD, there were significant differences between N and B-I（p＜0.01）, N and E（p＜0.05）. For vitamine E, there were significant differences between A-I and B-I, A-I and B-I, B-II and E（all p＜0.01）. Histologic changes showed that the grade of tissue injury was more severe in B-I and B-II than in A-I, and was less in E than in B-II.
It is suggested that vitamine E protected cells from injury due to oxygen free radicals.

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