J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 834KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 93(5): 488-493, 1992

Original article

MORPHOMETRICAL ANALYSIS OF NON-CANCEROUS LIVER TISSUE WITH SPECIAL REFERENCE TO CLINICOPATHOLOGICAL FEATURES OF HEPATOCELLULAR CARCINOMA

1) First Department of Surgery, Kobe University School of Medicine, Kobe, Japan
2) First Department of Pathology, Kobe University School of Medicine, Kobe, Japan

Takeshi Iwasaki1)2), Yonson Ku1), Yoichi Saito1), Hiroshi Ito2)

This study was undertaken to investigate the relationship between morphometrical characteristics of non­-cancerous liver tissues and clinicopathological features of hepatocellular carcinoma (HCC) in 89 cases which underwent either hepatectomy (n=56) or autopsy (n=33). Using Automatic Image Analyzer (IBAS-2), we determined interstitial ratio (IR) of the non-cancerous liver tissues as a morphological parameter in all cases. In addition, mean values of area (MA), maximal diameter, and shape factor of pseudolobules were determined in the cirrhotic patients.
IR in cases with main tumors smaller than 3cm was higher than that in cases with tumors larger than 3cm (23.5±6.7% vs 18.5±8.9% mean±SD: p<0.01), and IR in cases with histologically proven intrahepatic metastases (im positive) was also higher as compared to im negative cases (17.5±9.0% vs 21.3±8.0%; p<0.05). Among the other parameters determined in the cirrhotics, MA was higher in cases with tumors larger than 3cm than in cases with smaller tumors (2.54±1.87mm2vs 1.78±1.01mm2; p< 0.05), and MA was higher in im positive cases as compared to im negatives (2.67±1.91mm2 vs 1.67±0.96mm2;p<0.01).
These data indicated that non-cancerous liver tissue has a close relation not only to the carcinogenesis but to subsequent tumor growth and progression of HCC.

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