J.Jpn. Surg. Soc.. 93(3): 300-305, 1992

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Original article

THE EFFECT OF PROSTACYCLINE (PGI₂) ON DENERVATED TISSUES
-ESPECIALLY, ABOUT DENERVATION SUPERSENSITIVITY-

It is well known that contractive agents of smooth muscle have denervation supersensitivity. But, the existence of denervation supersensitivity in relaxed ones does not become so clear. We investigated these supersensitivity, especially prostacyclin (PGI₂).
We made the denervated artery by lumbar sympathetic ganglionectomy in mongrel dogs. Namely, saphenous and dorsal pedal arteries were denervated by this ganglionectomny. And we studied the changes of these arterial tensions by magnus apparatus.
Dose-response (D-R) curves of denervated arteries for KCl and noradrenalin (NE) shifted to left against control arteries. Next, we studied effects of PGI₂. At first, we measured ED₅₀ of KCl and NE contraction. And, we produced the half contraction on each artery by using ED₅₀ of KCl and NE. Lastly, PGI₂ was added on the half contractive arteries to study relaxed changes. D-R curves of denervated arteries for PGI₂ shifted to left, too. These denervated arteries acquired the supersensitivity for PGI₂.
Clinically, if we use relaxants after organ transplantation, these drugs may be very effective for the perfusion of the grafts.

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