[
Abstract]
[
Full Text PDF] （in Japanese / 725KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 93(2): 197-207, 1992
Original article
AN EXPERIMENTAL STUDY OF MYONEPHROPATHIC METABOLIC SYNDROME (MNMS)
We have attempted to establish dog experimental model similar to clinical MNMS. Thirty-five dogs were divided into four groups; G-1: Ligation of abdominal aorta.(N=5), G-2 : Ligations as above for 6 hours and reperfusion. (N=12), G-3 : Same as G-2+ligation of superior epigastric arteries(N=13), G-4: Same as G-2+transection of abdominal muscles (N=5). Biochemicals, electrolytes and blood gas analysis in artery and vein were measured before, 6 hours after clamp, 5 minutes, 1 hour, 6 hours after reperfusion. Skeletal muscle Pco
2, pH of lower leg were continuously measured. In G-1, no dog showed MNMS, in G-2, half of the dogs developed MNMS, in G-3, MNMS developed 9, but not in 4. In G-4, 4 dogs died during aortic cross-clamping. Satisfactory results were obtained in G-3. From the results of statistical analysis, the measurement of GOT, LDH, CPK, Cr and tissue Pco
2, pH showed high significance between MNMS (+) and (-), and had correlation with K, BE, pH of artery and vein after reperfusion. Therefore, we consider that above factors are appropriate predictors for MNMS.
To read the PDF file you will need Adobe Reader installed on your computer.