J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 598KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 93(2): 183-188, 1992

Original article

HISTOLOGICAL AND BIOLOGICAL EVALUATION OF PREOPERATIVE RADIOTHERAPY ON T1N0 BREAST CARCINOMAS

1) Department of Surgery, National Cancer Center Hospital, Tokyo, Japan
2) Radiology Division, National Cancer Center Hospital, Tokyo, Japan
3) Pathology Division, National Cancer Center Hospital, Tokyo, Japan

Takashi Fukutomi1), Hiroshi Yamamoto1), Takeshi Nanasawa1), Iwao Tsukiyama2), Hisashi Ogino2), Masayuki Itabashi3), Teruyuki Hirota3)

In order to clarify the role of radiotherapy in breast preserving surgery for early breast cancer, histological and biological effects of preoperative radiation were evaluated. Thirty-five T1N0 patients were treated by preoperative radiotherapy with beta-tron, cumulative doses of which were ranging from 25Gy (5Gy×5) to 40Gy (8Gy×5) and underwent subsequent modified radical mastectomy 2 or 3 weeks after the termination of radiotherapy. Cinical tumor shrinkage more than 50% was observed in 25 out of 35 cases (71%) but did not directly correlate with histological effects. Radiotherapy was basically ineffective within 25~30Gy, whereas histological effects more than Grade 2 were gained in 8 out of 25 patients (32%), who had received 40Gy or more. In the preoperative radiation group, there were more ER(+), PgR(+) and histologically well-differentiated cases than in the nonradiated stage I patients. Mitotic figures were also significantly reduced after radiotherapy, whereas the expression of c-erbB-2 protein was unchanged between these two groups. Our data indicate the various radiosensitivity of breast cancer cells and the indication of hormone therapy for the conservative treatment of breast carcinoma.

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