J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1680KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(11): 1608-1616, 1991

Original article

EFFECTS OF SUBLETHAL ENDOTOXEMIA TO THE HEPATIC RETICULOENDOTHELIAL
SYSTEM AFTER MASSIVE HEPATECTOMY

1) The Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
2) The Second Department of Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan

Hirotoshi Maruo, Satoshi Nakamura1), Hiroyuki Muro2)

Sublethal doses (1mg/kg) of endotoxin (ET) were intravenously administered on the first, third and fifth days after 34%, 70%, and 84% hepatectomies in rats. The same hepatectomy groups of rats without ET administration were made. Survival rates, distribution of Kupffer cells (Kc), regeneration rate of the liver weight, carbon clearance test (K value) and PTAH statning were compared between ET treated and untreated grotips.
Survival rates of 84% hepatectomy rats with ET injection on the 3rd postoperative day (POD) was significantly lower than those of 70% hepatectomy rats witli ET on the 1st or 3rd POD. ET activated reticuloendothelial function of the non-hepatectomized and 34% hepatectmy rats, but reduced the number of the Kc in the central zone, especially in 84% hepatectomized rats. K values and the number of Kc in the centraf zone showed a good correlationship (r=0.9) after 70% and 84% hepatectomies. Patchy hepatic necrosis and fibrin clots were observed histologically in the liver, kidney and spleen of rats died after ET administration.
In conclusion, sublethal endotoxemia reduces the function and number of Kupffer cells in the regenerating liver and causes postoperative death in the rats with massive hepatectomy.

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