J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2006KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(11): 1571-1576, 1991

Original article

POSTOPERATIVE CHANGES IN IMMUNOREACTIVE PLASMA ENDOTHELIN CONCENTRATIONS

1) First Department of Surgery, School of Medicine Tokyo Medical and Dental University, Tokyo, Japan
2) Second Department of Medicine, School of Medicine Tokyo Medical and Dental University, Tokyo, Japan

Kin-ichi Ito1), Narihide Goseki1), Mitsuo Endo1), Yukio Hirata2), Fumiaki Marumo1)

We investigated postoperative changes in immunoreactive plasma endothelin (ET-1) concentrations using a highly specific and sensitive radioimmunoassay developed for this purpose. The patients were divided into two groups:10 patients underwent subtotal-esophagectomy by combined right thoracotomy and celiotomy (EC-group), and an other 10 underwent total gastrectomy via celiotomy only (GC-group). Before operation, plasma ET concentrations in both groups were within the normal range. After operation, the mean plasma ET-1 concentration in the EC group was significantly higher than the preoperative concentration (p＜0.01). But in the GC-group, there were no significant change. A significent correlation existed between the change in plasma ET-1 concentration and the amount of intraoperative hemorrhage (p＜0.05). Additionally in the EC group, a significant correlation existed between plasma ET-1 concentrations after operation and the change in the atrial-natriuretic-peptide (ANP) concentration during operation (p＜0.05). There was no correlation between ET-1 concentrations and blood pressure.
We believe that the increase in the ET-1 concentration was attributable to endothelial cell injury and may increase ANP secretion. We speculate that the plasma ET-1 concentration may be a reliable index of surgical stress.

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