J.Jpn. Surg. Soc.. 92(9): 1229-1233, 1991

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Report on the annual meeting

SPLENIC OR HEPATIC ARTERIAL INJECTIONS OF INTERLEUKIN-2 WITH CHEMOTHERAPEUTIC AGENTS FOR HEPATIC METASTASES

Splenic or hepatic arterial injections of interleukin-2 (IL-2) with chemotherapeutic agents were performed in colorectal cancer patients with metastasis of the liver. LAK/NK activities in PBL from the patients receiving IL-2 plus cyclophosphamide (CY) splenic infusion were much potent than those of the patients receiving IL-2 alone. Twelve patients were treated with hepatic arterial infusions of IL-2 and mitomycin C (MMC) /5 fluorouracil (5FU).
Ten patients were evaluable and remaining 2 cases were not evaluable because of having no measurable lesion ; prophylactic infusion for occult metastasis after hepatectomy. Six out of 10 had a complete or partial response (60%), especially all patients receiving 6 months and more (3 cases) had a complete response (100%) and CEA level decreased to normal range. Lymphocyte phenotype study showed notable decrease in CD8⁺, 16⁺, 57⁺ cells and increase in CD4⁺ cells (elevation of 4/8 ratio) during the therapy. NKa ctivity was closely related to the percentage of CD 16⁺, 57⁺ cells in peripheral blood lymphocytes (PBL). These results might be reflected the dramatic accumulation of cytotoxic cells to the liver by the direct activation of hepatic sinusoidal endothelium due to IL-2 perfusion.

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