J.Jpn. Surg. Soc.. 92(8): 1001-1009, 1991

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Original article

RELATIONSHIP BETWEEN THE PROGNOSIS AND THE MORPHOLOGY OF STROMAL INVASION OF THE BREAST CANCER

I studied on the relationship between the prognosis and the invasion of the breast cancer clinicopatho- logically. Eight hundred and thirty-nine cases which had invasive cancer foci and mastectomized between 1950 and 1964 at the Cancer Institute Hospital were analyzed. The largest length of the invasive focus was measured histologically as the invasion size. To evaluate quality of the invasion, all invasive foci were analyzed about the composition of 5 morphological types of invasion, which consisted of one type with tubular formation (papillotubular-cribriform)and 4 types without tubular formation(medullary, small nest, pure scirrhous and mucinous). With proportion to the invasion size, 10-year survival rates were gradually diminishing. Cases with 20mm or less invasion size had better prognosis than cases with more than 20mm invasion size. Between tumors consisted with only one morphological type of invasion and tumors consisted of more than one types, the former had better prognosis than the latter. Cases with tubular formation had better prognosis than cases without tubular formation. In conclusion, the invasion size was the most valuable prognostic factor. About quality of the invasion, invasion focus consisted of only one histological type of invasion or of tubular formation was the indicator for better prognosis.

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