J.Jpn. Surg. Soc.. 92(8): 940-950, 1991

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Original article

STUDY OF PARAMETERS TO EVALUATE THE GRADE OF MALIGNANCY OF COLORECTAL CANCER WITH SUBMUCOSAL INVASION

Histological sections were prepared from 69 cases of colorectal cancer and the following 3 parameters were determined:A)the area of malignant change (mm²), B)the area of malignancy in the submucosal layer (mmb), and C)the proportion of B to A (%). The relationship between these parameters and biological malignant findings (lymph node metastasis and lymphatic and/or venous invasion) was investigated.
There was no relationship between A and biological malignant findings. Lesions with B values of less than 7.5mm² were not associated with biological malignant findings but those with values more than 30mm² always were. A significant difference in B values was noted between patients with and without these findings (22.0±13.2mm² vs. 6.5±7.0mm², p＜0.01). C values of more than 45% were always associated with biological malignant findings but values less than 20% never were. A significant difierence in C values was observed between patients with and without these findings (57.6±22.1% vs. 14.1±11.3%, p＜0.01).
These results suggested that the area of malignancy in the submucosal layer and its percentage to the entire area of malignant change on the histological sections were useful parameters to evaluate the grade of malignancy of invasive colorectal carcinoma.

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