J.Jpn. Surg. Soc.. 92(7): 794-806, 1991

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Original article

CHANGES IN CARDIORESPIRATORY FUNCTION AFTER RADICAL ESOPHAGECTOMY BY BILATERAL THORACOTOMY APPROACH IN DOGS

Twenty eight dogs (10～16 kg) were anesthtized with pentobarbital sodium, buprenorphine and pancuronium bromide followed by endotracheal intubation in the supine position. Twenty eight dogs were divided into two groups. Group 1 (n=14) underwent thoracic esophagectomy with regional lymph nodes dissection under the right thoracotomy. Group 2 (n=14) underwent the same manner of group 1. And left thoracotomy was added in the 5th intercostal space to completely dissect the left side regional lymph nodes. During stfrgical procedure, lactated Ringer's solution (L-R) were administered, L-R and Dextrane 40 were given for postoperative fluid therapy. Cardiac output (CO), pulmonary arterial pressure (PAP), pulmonary wedge pressure (PWP), mean arterial pressure (AP), heart rate (PR), extravascular lung water (EVLW), blood gas analysis, pulmonary shunt rate (Q_s/Q_t), lung resistance (R_L),· dynamic lung compliance (C_L) and colloid osmotic pressure (COP) were measured at preoperative phase and 1, 3, 6, 12 hrs after surgery.
Significant differences were found in the left ventricular stroke work index (LVSWI), R_L and the dosage of L-R between these dogs in-groups 1 and 2.
From these results, extended radical esophagecotmy by bilateral thoracotomy approach for clinical cases seems to be possible under the exact indication and intensive perioperative care.

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