J.Jpn. Surg. Soc.. 92(6): 734-739, 1991

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Original article

EFFECTS OF SYNGENEIC PRESERVED BLOOD CELLS ON METASTATIC GROWTH OF THE LEWIS LUNG CARCINOMA

Each of B6C3HF1 mice was infused with stored syngeneic blood cells, fresh syngeneic blood cells, or saline, and then was injected intravenously with 1×10⁶ Lewis lung carcinoma cells. Survival rate of each group declined in order of the saline group, the fresh-cell group, and the stored-cell group with a significant difference between all paired groups (P＜0.001). When the number of metastases and ¹²⁵I-Iododeoxyuridine uptake in the lungs and livers were compared between these groups, there were significant differences with greater number and uptake in the stored-cell group than the fresh-cell group or the saline group on day 15 through 17, and greater in the fresh-cell group than the saline group on day 23 and 24. In the second experiment, each mouse was inoculated sptbcutaneously with 1×10⁵ tumor cells. Twenty-one days later, the subcutaneous tumors were removed, and the mice were infused with blood cells or saline immediately. The number of lung metastases of the stored-cell group was significantly larger than that of the fresh-cell group or the saline group on 9 and 11 days following tumor removal. In conclusion, the transfusion of the preserved syngeneic blood cells was considered to enhance both artificial and spontaneous metastasis of the Lewis lung carcinoma.

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