J.Jpn. Surg. Soc.. 92(6): 707-715, 1991

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Original article

EXPERIMENTAL STUDY ON THE CHARACTERISTIC FEATURES OF SYMPATHETIC NERVOUS SYSTEM REACTIONS IN DOGS WITH OBSTRUCTIVE JAUNDICE

Possible abnormalities in the sympathetic nervous system responsible for circulatory disturbances with obstructive jaundice were investigated by determinating the reactions of the heart and peripheral blood vessels using α･β receptor stimulants or blockers. Mongrel dogs were randomly assigned to three groups:untreated (UT) and sham-operated (SO) controls and 3-week-old bile duct ligated(BDL). Under anesthesia with Nembutal, circulatory parameters and blood catecholamine concentration were measured. In term of α-and β-adrenergic reactions, reactions in the sympathetic nervous system to α-and β-receptor stimulants were examined. Mean arterial pressure (MAP) and heart rate were used as an α-adrenergic parameter and a β-adrenergic parameter, respectively. The hemodynamic study in BDL group was characterized by a reduction in MAP (p＜0.05), total peripheral resistance (p＜0.005) and left ventricular stroke work (LVSW) (p＜0.05) and by an increase in cardiac index (p＜0.05). The blood norepinephrine concentration was significantly increased in jaundice (p＜0.01). Reaction to the β-receptor stimulant was significantly decreased in BDL group. In response to the α-receptor stimulant, lower reactivity was found in some animals in BDL group in comparison to SO group. Taking this into consideration with the increase in blood norepinephrine and the decrease in LVSW, the presence of abnormalities particularly in the β-adrenergic system (receptor, cardiac muscle etc.) in jaundice is suggested to be a characteristic feature of reactions in the sympathetic nervous system, Such abnormalities are speculated to be responsible for postoperative shock.

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