[
Abstract]
[
Full Text PDF] （in Japanese / 2707KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 92(6): 664-671, 1991
Original article
PATIENTS WITH HIGH RISK OF HEMATOGENOUS METASTASIS AND RECURRENCE IN COLORECTAL CANCER: CORRELATION WITH HISTOPATHOLOGIC VARIABLES AND TUMOR MARKERS, CEA AND CA19-9, IN PERIPHERAL AND DRAINING VENOUS BLOOD
Correlations of hematogenous metastasis with histopathologic variables, preoperative CEA and CA19-9 levels in peripheral (p) venous blood, and those in draining (d) venous blood were examined in 78 patients with colorectal cancer. Out of 10 histopathologic variables, location of venous invasion was most significantly correlated with hematogenous recurrence:the rate (11%) of v
0 and/or sm-pm v
(+) in 50 patients without the recurrence was significantly lower than that (89%) in 28 patients with the recurrence. On the other hand, the rate (68%) of ss-extra
(+) in the latter was significantly higher than that (32%) of the former. The mean values (6 and 14ng/ml) and positive rates (22 and 48%) greater than 5ng/ml of p and d-CEA in 50 patients without the recurrence were significantly lower than those (14 and 189ng/ml, 48 and 96%) in 28 patients with the recurrence. Patients with d-p CEA gradient greater than 5ng/ml were found, respectively, in 34% of the former and 82% in the latter. The mean value (982U/l) and positive rate (94%) greater than 37U/ml of CA19-9 in peripheral blood of 28 patients with the recurrence were significantly higher than those (25U/ml and 11%) of 50 patients without the recurrence. These results suggest that colorectal cancer patients with high risk of hematogenous metastasis and recurrence are the patients with ss-extra
(+), the values of d-CEA, especially d-p CEA gradient, greater than 5ng/ml and with p-CA19-9 value greater than 37U/ml.
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