J.Jpn. Surg. Soc.. 92(6): 645-651, 1991

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Original article

EXPERIMENTAL STUDY OF THE EFFECT OF BILE JUICE ON THE REMNANT GASTRIC CANCER DEVELOPMENT

Experimental studies were performed to investigate the role, if any, of bile reflux in cancer development in the stomach. A 20% solution of human bile juice and 50µg/ml of the known carcinogenic MNNG were given perorally and heterochronically to male Wister rat, and the incidence of carcinoma in the gastric gland of the rat was studied. The animals were divided into 4 groups: Group I, to which only MNNG was given. Group II, to which human bile juice and then MNNG were administered. GroupIII, to which MNNG and then human bile juice were administered. And Group IV, to which only human bile juice was given. The incidence of cancer was 37.5% (3/8) in Group II, 25% (2/8) in Group III, and 0% in Group I (0/12) and IV (0/12). The gastric gland mucosa was histologically examined at various times and also by microautoradiography using ³H-TdR.
The results suggested that a reverse flow of bile juice to the human remnant stomach may induce an increase in proliferative cells in the lacuner epithelia of the stomach mucosa and that a predisposed site would then be available for cancer development.

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