J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 468KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(5): 598-602, 1991

Original article

PROLIFERATIVE ACTIVITY ASSESSED ON THE BASIS OF DNA PLOIDY
PATTERNS IN PRIMARY LUNG CANCER

1) First Department of Surgery, Nagasaki University, School of Medicine, Nagasaki, Japan
2) Department of Thoracic and Vascular Surgery, Oita Prefectural Hospital, Oita, Japan

Norio Yamaoka1)2), Yutaka Tagawa1), Kosei Miyashita1), Hiroyoshi Ayabe1), Katsunobu Kawahara1), Yoshitaka Uchiyama2), Masao Tomita1)

Flow cytometric cellular DNA-RNA content analysis by acridine orange staining was conducted on surgical fresh specimens of primary lung carcinomas from 66 patients (31 squamous cell carcinomas, 34 adenocarcinomas and l large cell carcinoma).The frequency of aneuploid tumors was 84.6% among the tumors. RNA content (RNA Index) in the DNA aneuploid tumor much more significantly (p＜0.05) increased than the DNA diploid tumor. Tumor doubling time in the DNA aneuploid tumor was significantly (p＜0.05) shorter than in the DNA diploid tumor. In the patients with lung cancers that recurred within 1 years, recurrence of the DNA aneuploid tumor was higher than the DNA diploid tumor.
It is evident from the above results that proliferative activity in the DNA aneuploid tumor increases much more than in the DNA diploid tumor. This in turn may induce early recurrence in patients with lung cancer.

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