J.Jpn. Surg. Soc.. 92(3): 293-302, 1991

---

Original article

ANALYSIS OF IMMUNOLOGICAL RESPONSE OF REGIONAL LYMPH NODE LYMPHOCYTES FROM PATIENTS WITH GASTRIC CANCER AFTER ENDOSCOPIC LOCAL INJECTION OF BIOLOGICAL RESPONSE MODIFIER (BRM)

Local injection of BRM (OK-432 or Lentinan) around the cancer lesions via endoscope was performed on 66 gastric cancer patients preoperatively, and the regional lymph node lymphocytes in the surgical specimens were examined on T-cell subset, production of IL-2, and responsiveness to IL-2.
The results were as follows:
1) In the metastatic lymph nodes, proportions of T-lymphocyte subsets, production of IL-2 and responsiveness to IL-2 did not change after local administration of OK-432 or Lentinan.
2) In the non-meastatic lymph nodes, percentage of CD4⁺4B4⁺cells were significantly increased and production of IL-2 was markedly augmented after local injection of OK-432. On the other hand, percentage of CD8⁺CDII^-cells were significantly increased and production of IL-2 was markedly enhanced after the local injection of Lentinan.
These data suggested that the antitumor response of the non-metasatic lymph node lymphocytes was augmented after the local injection of OK-432 or Lentinan.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.