J.Jpn. Surg. Soc.. 92(2): 150-159, 1991
Original article
BENEFICIAL EFFECTS OF FRUCTOSE-1,6-DIPHOSPHATE INFUSION ON HEPATIC REGENERATION AFTER PARTIAL HEPATECTOMY BY MICROWAVE TISSUE COAGULATOR
|
Department of Gastroenterological Surgery, Wakayama Medical College, Wakayama, Japan Takehiro Nakai, Hiroshi Tanimura, Katsuyoshi Tabuse, Yugo Nagai, Kazunari Mori, Hideki Yamoto |
Concerning the effect of MTC on hepatic regeneration, a MTC group showed a significantly higher serum LDH level on post-operative day 2, compared with a simple ligation group. A significant difference in DNA synthesizing activity between two groups was noted only in the peripheral region of regenerating liver tissue. A marked depression was observed on post-operative day 2 in the MTC group, 433±50dpm/μg DNA as compared to 782±111dpm/μg DNA in the simple ligation group, and also in respect of protein synthesis and labeling index.
Administration of FDP prior to operation brought about a complete inhibition of the serum LDH elevation. DNA synthesis was significantly enhanced in the peripheral region of regenerating liver tissue in rats pretreated with FDP (422±52,783±112 and 912±115dpm/μg DNA in the saline, FDP 0.25mmol/kg and FDP 0.8mmol/kg groups, respectively). Similar trends were observed as to protein synthesis and labeling index. FDP has been proven to be effective on protection of the liver cells as well as on promotion of the liver regeneration following hepatic resection by MTC.
To read the PDF file you will need Adobe Reader installed on your computer.