J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1474KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(11): 1710-1714, 1990

Original article

EFFECT OF GLUCAGON ON BILE ACID AFTER HEPATECTOMY IN PATIENTS WITH HEPATOCELLULARCARCINOMA ASSOCIATED WITH CIRRHOSIS

Second Department of Surgery, Kinki University School of Medicine, Osaka, Japan

Takaaki Sudo, Hideaki Bessho, Masaaki Miyamoto, Chikao Yasuda, Takahisa Uchida, Masao Kawamura, Takeshi Kuyama

Hepatic function frequently becomes worse, after hepatectomy in patients with hepatocellular caricnoma associated with cirrhosis. We usually use insulin and glucagon to treat patients with poor hepatic function, so we examined hepatic function in these patiens in relaion to bile acid meabolism.
1) Total serum bile acid levels were increased in patients with cirrhosis, and serum GCDCA, TCDCA values were especially high. After surgery, they rose even higher.
2) Glucagon was shown to stimulate CAMP and decreased total serum bile acid, and especially serum GCDCA and TCDCA values.

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