J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2473KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(10): 1603-1607, 1990

Original article

EFFECT OF HIGH DIETARY FAT ON THE TOTAL DNA AND RECEPTOR CONTENTS IN RATS WITH 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED MAMMARY CARCINOMA

1) Operation Center, Kanazawa University Hospital, Kanazawa, Japan
2) The Department of Surgery (II), School of Medicine, Kanazawa University, Kanazawa, Japan

Masakuni Noguchi1)2), Takeo Kumaki2), Takao Taniya2), Naohiro Koyasaki2), Itsuo Miyazaki2)

The influences of high dietary fat on the malignant intensity and the hormone receptors of DMBA-induced mammary breast carcinoma were analyzed in female Sprague-Dawley rats. The rats were fed either a low-fat diet or high-fat diet after the DMBA administration. As the results, incidence, size, average latent period, DNA histogram, DNA index and % of S-phase fraction of tumor were significantly different between both groups. But the ER and PgR contents were not different between both groups. The results suggest that a high dietary fat could increase the malignant intensity of the tumor but does not influence the receptor contents of the tumors.

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