J.Jpn. Surg. Soc.. 91(9): 1283-1286, 1990

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Report on the annual meeting

COMBINED THERAPY OF HYPERTHERMO-LOCAL CHEMOTHERAPY FOR PREVENTING OF LOCAL RECURRENCE AND TREATMENT OF LOCAL RECURRENCE CASES IN RECTAL CANCER

In order to prevent local recurrence of rectal cancer postoperatively, we attempted to use preoperative irradition, 5-fluororacil (5-FU) or both. Recently, we treated rectal cancer patients using irradiation, hyperthermia and 5-FU suppository. Hyperthermia was carried out using endotract electrode equipped with radiofrequency system. The preoperative combined therapy of irradiation, hyperthermia and 5-FU suppository produced excellent tumor response in comparison to other treatment groups. Cancer invasion to the external wall of the rectum was remarkably reduced by irradiation, hyperthermia and 5-FU suppository. No postoperative death cases and no local recurrence cases were observed in irradiation, hyperthermia and 5-FU suppository combined group. Furthermore, combined therepy of hyperthermia and infusion of cisplatinum and 5-FU was effective for local recurrence of rectal cancer. In conclusion, the preoperative combined therapy is expected to reduce local recurrence of rectal cancer.

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