J.Jpn. Surg. Soc.. 91(8): 1044-1047, 1990

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Case report

A CLINICAL CASE OF ABO-INCOMPATIBLE LIVING RENAL TRANSPLANTATION

We successfully made ABO-incompatible renal transplantation, of which report is methodologically the first in Japan and probably the second in the world to our knowledge. Sixty year-old-female (mother) with B-blood type donated her right kidney to 36 years-old male (son) with O-blood type. Pretransplant removal of plasma isoagglutinin of the recipient through plasma exchange with albumin solution followed by hemodialysis with administration of fresh frozen B-type plasma effectively reduced the anti-BlgM-antibody titre of ×256 to ×8 and the anti-lgG antibody titre of ×512 to ×16. Splenectomy was performed at the time of transplantation. On the 10th POD, the anti-B antibody titres were more decreased to IgM antibody ×2 and IgG antibody ×8. Patient is doing well without any sign of rejection as of 4 months postoperatively.

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