[
Abstract]
[
Full Text PDF] （in Japanese / 2439KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 91(8): 980-986, 1990
Original article
CLINICAL SIGNIFICANCE OF DNA CONTENT OF RECTAL CANCER MEASURED BY FLOW CYTOMETORY
DNA content of 369 rectal cancers was measured by flow cytometory. One hundred and four (28.2%) were diploid, 252 (68.3%) were aneuploid and 13 (3.5%) were tetraploid. Diploid cancers were associated with an improved 5 year survival (p＜0.001) and were more likely to be diagnosed at an early stage. However DNA content did not confer independent prognostic information in a Cox model based on four discrete pathological variables. Patients were classified by a new system of prognostic groupingand those with a very good or a very poor outlook were removed leaving 137 prognostic group 3 patients. No further substratification of this group by DNA content or by four additional pathological variables could be achieved. As the new prognostic system is not improved by the additional of ploidy, routine adoption of flow cytometry in the assessment of rectal cancer can not be recommended.
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