J.Jpn. Surg. Soc.. 91(3): 386-392, 1990

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Original article

CHANGES OF ARTERIAL THROMBOXANE B₂ AND 6-KETO-PROSTAGLANDIN-F_1α LEVELS IN CIRRHOTIC AND NON-CIRRHOTIC PATIENTS AFTER HEPATECTOMY

Foliowing hepatectomy, arterial concentrations of thromboxane B₂ (TXB₂) and 6-keto-prostaglandin F_1α (6-keto-PGF_1α), which are stable metabolites of thromboxane A₂ (TXA₂) and prostaglandin I₂ (PGI₂), were measured by radioimmunoassey in 17 cirrhotic and g non-cirrhotic patients to assess the role of TXB₂ and PGI₂ in patients with liver dysfunction during hepatectomy. In both cirrhotic and noncirrhotic patients, arterial TXB₂ and 6-keto-PGF_1α levels significantly increased during hepatectomy and decreased to preoperative levels at the lst postoperative day (1-POD). The TXB₂/6-keto-PGF_1α ratio significantly decreased during hepatectomy and at 1-POD. There were no significant differences in changes of TXB₂ and PGI₂ levels between cirrhotic and non-cirrhotic patients. In cirrhotic patients with poor hepatic reserve, whose ICG K values were less than 0.08, arterial 6-keto-PGF_1α levels were significantly higher and the ratio were significantly lower than in cirrhotic patients with good hepatic reserve and non-cirrhotic patients before and after operation. Based on these results, it is concluded that the TXA₂/PGI₂ ratio becomes low after hepatectomy and the ratio is lower in cirrhotic patients with poor hepatic reserve.

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