[
Abstract]
[
Full Text PDF] （in Japanese / 2665KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 91(2): 201-205, 1990
Original article
CLINICAL RESULTS OF INTRAPERITONEAL HYPERTHERMIC PERFUSION COMBINED WITH SURGERY FOR PATIENTS WITH PERITONEAL RECURRENCE FROM GASTRIC CANCER
Six patients with peritoneal recurrence after radical operation for gastric cancer were treated by an intraperitoneal hyperthermic perfusion (IPHP) combined with surgery (IPHP group). Immediately after surgery, a 2-hour IPHP was performed, using a perfusate containing 10μg/ml of MMC, warmed at the inflow temperature of 46.5±1.1℃. Within the sarne period of time, 5 patients with intra-abdominal recurrent gastric cancer (control group) were treated by an intraperitoneal administration of MMC 10mg combined with surgery. These 11 patients had malignant peritoneal effusion and, although in 3 of the control group, ascitic effusion did re-accumulate rapidly soon after surgery, the 6 patients of IPHP group did not re-accumulate post-hyperthermically. The average survival duration of IPHP group is 13.6±10.6 months, whereas that for controls is 3.0±2.1 months. Again, the survival rate for IPHP group surpassed that for controls at p=0.012 and p=0.008, in a generalized Wilcoxon method and Logrank method, respectively. Post-hyperthermically, hypoproteinemia and thrombocytopenia occurred transitorily. These results show that IPHP using MMC combined with surgery is a safe, reliable treatment for patients with peritoneal recurrence due to gastric cancer.
To read the PDF file you will need Adobe Reader installed on your computer.