J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 648KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 90(11): 1829-1833, 1989

Original article

EFFECT ON IMMUNOLOGICAL RESPONSE OF HOST BY MITOMYCIN C ADSORBED ONTO ACTIVATED CARBON PARTICLES (MMC-CH) IN MICE

The 1st Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan

Akihiko Iwamoto, Masakazu Sakita, Koki Hata, Akeo Hagiwara, Toshio Takahashi

Mitomycin C adsorbed onto activated carbon particles (MMC-CH) has been administered intraperitoneally for C57BL/6 mice. The weight of the spleen and thymus of the mice given MMC-CH was decreased lesser than those of the mice given mitomycin C aqueous solution (MMC-AQ). The number of peritoneal exudate cells (PEC) in the mice given MMC-AQ was decreased remarkably on 1st day after MMC-AQ administration and recovered within normal range on the 7th day.
On the other hand, the number of PEC in the mice given MMC-CH was increased remarkably on the 1st day and then gradually decreased to normal range on the 7th day. Rectivity of spleen cells by Con A was inhibited in the spleen cells from the mice given MMC-AQ more than those from the mice given MMC-CH.
Fifth percent lethal dose was 8.0mg/kg in the mice given MMC-AQ, and 18.2mg/kg in the mice given MMC-CH.

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