J.Jpn. Surg. Soc.. 90(10): 1774-1779, 1989
Original article
CHANGES OF HEPATIC AND RENAL TISSUE BLOOD FLOWS OF CIRRHOTIC RAT IN HEMORRHAGIC SHOCK
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The 1st Department of Surgery, Tohoku University School of Medicine, Sendai, Japan Tsuneaki Fujiya, Kiyoaki Ouchi, Seiki Matsuno |
The changes of hepatic and renal tissue blood fiows (TBF) were studied in hemorrhagic shock using cirrhotic rats. The hepatic and renal energy charges (EC) were measured in normal and cirrhotic rats.
Hepatic TBFs of the cirrhotic rats decreased to 74% of the normal, portal pressure increased to 140%, but renal TBF was not changed significantly. In hemorrhagic shock induced by blood exanguination, hepatic and renal TBFs of normal rats were restored to the preshock levels by transfusion of shed blood, but those of cirrhotic rats were not restored. Futhermore, the hepatic and renal ECs of normal-shocked rats were not different from those of control rats, but the ECs of cirrhotic-shocked rats were decreased significantly.
These findings suggest that hypotention under cirrhosis disturbs hepatic and renal tissue circulations and energy metabolisrns also in a period of after-shock phase.
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