J.Jpn. Surg. Soc.. 90(10): 1742-1751, 1989

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Original article

IMMUNOHISTOCHEMICAL AND CLINICOPATHOLOGICAL STUDIES OF CHROMOGRANIN IMMUNOREACTIVE CELLS IN LARGE BOWEL CARCINOMA

We examined the clinicopathological relevance of chromogranin immunoreactive cells in a well documented series of 212 large bowel cancer patients. Chromogranin immunoreactive cells were detected in 33.5% of the carcinomas, occurring either as rare cases (19.3%) or as diffuse cases (14.2%). The tumors with chromogranin immunoreactivity were associated with a more aggressive clinical course than tumors without immunoreactivity (Generalized-Wilcoxon ; p＜0.08). Moreover, the survival of patients with diffusely immunorective tumors was significantly shorter than that of patients without such cells (Generalized-Wilcoxon ; p＜0.009). Therefore, the study of chromogranin immunoreactivity in large bowel carcinomas may enable the identification of a subpopulation of colorectal carcinomas associated with a relatively poor prognosls.

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