J.Jpn. Surg. Soc.. 90(9): 1579-1581, 1989
Report on the annual meeting
AMPLIFICATION AND EXPRESSION OF ONCOGENES IN HUMAN MALIGNANT TUMORS
―ORGAN OR TISSUE SPECIFICITY AND PROGNOSIS―
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Dept. Surg. School of Medicine, Keio University, Tokyo, Japan Masakazu Ueda, Nobuyoshi Shimizu*), Osahiko Abe |
Amplification of c-erb B oncogene is detected in 12％ of squamous cancer tissues such as cancer of the lung and esophagus, but not others. That of c-erb A and c-erb B-2 oncogenes is, specifically, detected in 20－25％ of breast cancers. On the other hand, amplification of c-myc is detected in 10－20％ of various cancers.
EGF receptors is highly and specifically, overexpressed in squamous cancers, and the prognosis of the patients with amplificatin and overexpression of c-erb B oncogenes is poor.
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