J.Jpn. Surg. Soc.. 90(6): 894-906, 1989
Original article
HISTOGENESIS OF GALLBLADDER CANCER WITH SPECIAL REFERRENCE TO METAPLASTIC CHANGES AND DISTRIBUTION OF VARIOUS MUCINS AND CEA
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The First Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan Akio Inada, Fumio Konishi*), Noboru Yamamichi**), Hiroshi Ito***) |
Intestinal metaplasia was observed more frequently in the cases of cancer,both in cancerous and non-cancerous tissues, than those of chronic cholecystitis. In addition, CPS III type of mucin, which is preferably demonstrated in the pyloric glands, was observed in the tumor cells of 50％ of cancers. Thus, gastric metaplsia as well as intestinal metaplasia seemes to be important as a predisposing lesion to gallbladdelr cancer.
By means of reconstruction method carried out on the specimens of cancer, multifocal gradual transition among metaplasia,dysplasia and cancer was observed and dysplsia is an important step in cancer development.
As for mucin secretion, the rate of sialomucin-contaning cells was notably high in the lesions of dysplasia and cancer, increasing in intensity in this order, accampanied with positive CEA.
The results of the present study support the hypothesis that cancer arises from such pre-existing mucosal lesions as metaplasia and dysplasia.
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