J.Jpn. Surg. Soc.. 90(6): 826-836, 1989

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Original article

EFFECTS OF ENDOCRINOLOGICAL FUNCTION OF ANTRUM ON ACID SECRETION OF PARIETAL CELL IN PATIENTS WITH DUODENAL ULCER

Antral G and D cells were microscopically counted by the immunoperoxidase method in the resected stomachs of 18 patients with duodenal ulcer (DU group), 4 with recurrent duodenal ulcer after selective proximal vagotomy (SPV-REC group) and 6 with early gastric cancer in the corpus (control group). In DU and SPV-REC groups, preoperative acid secretion stimulated by the tetragastrin (Tg-MAO, Tg-PAO) was examined. In 9 patients of DU and SPV-REC groups, adrenalin stimulated acid secretion (Adr-PAO) and integrated gastrin resonse (Adr-PGO) were also examined.
The G cell count in DU group (Tg-MAO≧20) and SPV-REC group were significantly more than in DU group (Tg-MAO＜20) and control group. In DU and SPV-REC groups, a significant correlation was observed between Tg-PAO and total G cell coullt. In 9 DU patients, a significant correlation was observed between the total G cell count and Adr-PGO or Adr-PAO, between Adr-PGO and Adr-PAO or Tg-PAO and between Tg-PAO and Adr-PAO. The above results suggested that increase of antral G celI counts is one of the great cause of duodenal ulcer and recurrent ulcer after SPV, greately affecting on increase of acid secretion intermediating serum gastrin. Both Tg-PAO and Adr-PAO were regarded as good index of functional G cell mass of the antrum.

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