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Abstract]
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J.Jpn. Surg. Soc.. 90(5): 780-785, 1989
Original article
INFLUENCE OF ENDOCRINE THERAPY ON THE PROLIFERATION OF ESTROGEN (ER) POSITIVE CELLS AND ER NEGATIVE CELLS OF HUMAN BREAST CANCER (MCF-7)
The influence of endocrine therapy on the proliferation of estrogen receptor (ER) positive cells and ER negative cells of human breast cancer (MCF-7) serially transplanted into nude mice was analyzed by tumor growth, dextran-coated charcoal (DCC) method, ER-immunocytochemical assay (ER-ICA) and ER-immunocytochemically stained
3H-thymidine autoradiography. In the tamoxifen (TAM) group and the medroxyprogesterone acetate (MPA) group, tumor growth was inhibited, but it was promoted in the 17β-estradiol dipropionate (E
2) group. The ER level by the DCC method significantly decreased in the TMA, the MPA and the E
2 groups. The ER-ICA showed that the ER positive cells rate in the TAM and the MPA group decreased, but it increased in E
2 group. However, the ER-immunocytochemically stained
3H-thymidine autoradiography showed that not only the labelling index of ER-positive cells but also that of ER negative cells significantly decreased in the TAM and the MPA groups, but significantly increased in the E
2 groups. Therefore it was concluded that endocrine therapy affected the proliferation of both ER positive cells and ER negative cells of ER positive breast cancer.
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