J.Jpn. Surg. Soc.. 90(4): 605-614, 1989

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Original article

LOCAL CHANGES IN PROSTANOIDS IN ARTERIOSCLEROSIS OBLITERANS

In order to identify local changes in prostanoids in arteriosclerosis obliterans (ASO), plasma levels of thromboxane B₂ (TXB₂) and 6-keto-prostaglandin F_1α (6-Keto-PGF_1α) in cubital venous blood (CV blood), in femoral arterial blood (FA blood) and in femoral venous blood (FV blood) of 27 patients with ASO of lower limbs and of 10 healthy controls were measured by RIA technique. The following results were obtained.
1) In the ASO patients, levels of TXB₂ and the ratio between TXB₂ and 6-Keto-PGF_1α (TXB₂/ 6-Keto-PGF_1α) in FV blood of ischemic legs were elevated in comparison to those in CV blood or FA blood of the same group or those in FV blood of the controls.
2) This change was more clearly observed in the femoro-popliteal group, but in the aorto-iliac+ combined group, they were elevated not only in FV blood but also in FA blood.
3) No significant difference was observed between the Fontaine I+II group and the Fontaine III+ IV group in these local changes in prostanoids.
4) The severer the angiographic manifestation between the abdominal aorta and the common femoral artery, the higher the plasma TXB₂ levels in FA blood. Also, the poorer the peripheral run-off, the higher the plasma TXB₂ production in the legs.
These results suggest that the imbalance between TXA₂ and PGI₂ is obvious in ischemic legs of ASO patients, TXA₂ is elevated downstream from damaged vessels, and the local plasma TXB₂ levels reflect the severity of the vascular damage in ASO patients.

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