J.Jpn. Surg. Soc.. 90(4): 566-572, 1989
Original article
LIVER FAILURE AFTER HEPATIC RESECTION
|
The First Department Surgery, Fukui Medical School, Fukui, Japan Hiroshi Shimada, Akira Matsuba, Shuichi Nimoto, Hideharu Fujita, Gizo Nakagawara, Shuji Tsuchiya*) |
In the control group (n=44) and the bile stasis group (n=9) plasma endotoxin increased to 22 to 160pg/ml early after operation and decreased thereafter:but in the liver failue group (n=10) it increased higher corresponding to high risk operation and the massive bleeding or anastomosis leakage.
In control and bile stasis groups phagocytic K value, serum CH50, plasma fibronection decreased to half of the preoperative level on the first postoperative day, and later improved. In liver failure group these levels decreased but never improved.
Liver failure group was characterized by an irreversible platelets count decrease corresponding to the increase of serum bilirubin level.
It was concluded that endotoxemia in the presence of a self defence system dysfunction is thought to be a trigger for organ failure.
To read the PDF file you will need Adobe Reader installed on your computer.