J.Jpn. Surg. Soc.. 90(4): 538-545, 1989

---

Original article

ANTI-TUMOR EFFECT OF FLUOROPYRIMIDINES ON HUMAN TUMOR CELL LINES TRANSPLANTED IN NUDE MICE WITH CCl₄-INDUCED LIVER DYSFUNCTION

Tegafur(ET)is a masked compound of 5-fluorouracil (5-FU) and supposed to be activated in the liver. The present study was designed to estimate anti-tumor effect of FT on human tumors transplanted in nude mice with liver dysfunction induced by CCI₄. Histologically, cirrhotic changes of liver were observed after injection with 1ml/kg 10% CCI₄ twice a week for 8 weeks. Mice were transplanted with human gastric (GC-SF) or colonic cancer (CC-ZK) lines, and daily administered intragastrically with 5-FU (15mg/kg), FT (100mg/kg) or UFT (FT 20mg/kg+Uracil 44.8mg/kg) for 4 weeks. The growth of GC-SF was enhanced by liver dysfunction, but that of CC-ZK was not affected. The mean growth inhibition rates (MGIR) of CC-ZK by 5-FU, FT or UFT were 18.3, 33.1 and 54.2%, respectively, in mice without liver dysfunction, and 14.0, 50.0 and 59.5%, respectively, in mice with liver dysfunction. The MGIRs of GC-SF were 39.0, 63.8 and 48.0%, respectively, in mice without liver dysfunction, and 12.6, 53.6 and 50.0%, respectively, in mice with liver dysfunction. In both lines effect of 5-FU was reduced in liver dysfunction, but those of FT and UFT was not. These results suggest that FT and UFT can be used for cancer patients with liver dysfunction.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.