J.Jpn. Surg. Soc.. 90(3): 385-395, 1989

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Original article

CHANGES OF POLY (ADP-RIBOSE) POLYMERASE ACTIVITY IN POST-HEPATECTOMIZED RAT LIVER NUCLEI WITH GLUCAGON AND INSULIN

To elucidate the effect of combined therapy of glucagon and insulin on the hepatectomized remnant liver of rats, postoperative changes of liver nuclear poly (ADP-ribose) polymerase activity were measured. The maximal value of poly (ADP-ribose) polymerase activity without glucagon and insulin was revealed as 354±44pmole/mg/min at the stage of 5 days after partial hepatectomy. In contrast, the enzyme activity with glucagon and insulin reached to peak value as 242±46pmole/mg/min at the stage of 2 days after hepatectomy. Liver weight regeneration rate of the group with glucagon and insulin showed higher values than that of the group without glucagon and insulin in the period from 5 to 21 days after hepatectomy. The amounts of DNA showed similar changes to poly (ADP-ribose) polymerase activity after hepatectomy. Thus it is suggested that the combined therapy of glucagon and insulin may act to promote liver regeneration through the changes of poly(ADP-ribose)polymerase activity.

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