J.Jpn. Surg. Soc.. 90(2): 250-257, 1989

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Original article

EFFECT OF ACTIVATION OF THE RETICULOENDOTHELIAL SYSTEM ON HEPATOCYTE REGENERATION IN PARTIALLY HEPATECTOMIZED RATS

Enhanced effect on rat hepatocyte regeneration through activation of the reticuloendothelial system (RES) was investigated. RES was activated using by OK-432 and the phagocytic activity (K-value) increased 2-fold over control rats 24 hours after intraperitoneal injection of OK-432. In OK-432 treated rats, the amount of cyclic AMP in the regenerating liver also increased 1.5-fold higher than in control rats 14 hours after hepatectomy. After 70% partial hepatectomy, liver DNA synthesis in OK-432 treated rats increased 2 to 5-fold higher than in control rats. There was a good correlation between the K-value before hepatectomy and DNA synthesis 24 hours after hepatectomy (r＝0.96). Therefore the RES is one of the most important regulatory factors in liver regeneration. Augumention of RES before hepatectomy may prevent hepatic failure after resection in liver diseases.

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