J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1811KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 90(2): 222-227, 1989

Original article

MONOCLONAL ANTIBODY NCC-ST-439 IN GASTRIC CANCER TISSUE

Second Department of Surgery, Kanazawa University School, Kanazawa, Japan

Toru Kamata, Yutaka Yoneumura, Kazuo Sugiyama, Akio Yamaguchi, Koichi Miwa, Itsuo Miyazaki

An immunohistochemical study revealed that NCC-ST-439 positive tumor were detected in 33％ of the 244 gastric carcinomas. The incidence of NCC-ST-439 immunoactivity in well differentiated adenocarcinomas (papillary and tubular adenocarcinoma) was significantly higher than in poory differentiated adenocarcinomas (including signetring cell and mucinous adenocarcinoma). Moreover, NCC-ST-439 immunoreactive tumors showed more frequent vessel invasion and higher DNA content than non-reactive tumors. The reccurrence rates of NCC-ST-439 immunoreactive tumors in the liver and lymph nodes were significantly higher than those of non-reactive tumors. Patients with NCC-ST-439 immunoreactive carcinoma had much worse prognosis than those with NCC-ST-439 non-reactive carcinoma. These results suggest that NCC-ST-439 antigen produced by tumor cells plays an important role in the invasive growth and vessel invasion and also serves as a biological marker of malignancy in patients with gastric cancer.

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