J.Jpn. Surg. Soc.. 89(12): 1965-1968, 1988
Original article
HUMAN EPIDERMAL GROWTH FACTOR (h-EGF) IN GASTRIC CARCINOMAS
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The Second Department of Surgery, Kanazawa University of Medicine, Kanazawa, Japan Sachio Fushida, Yutaka Yonemura, Kazuo Sugiyama, Hisashi Matsumoto, Touru Kamata, Kouichi Miwa, Itsuo Miyazaki |
Regarding macroscopic and histologic types, incidence of h-EGF immunoreactivities in infiltrating type and in poorly differentiated type was significantly higher than those in localized type and in differentiated type, respectively.
In addition, h-EGF producing carcinomas showed high positive rate in prognostic serosal involvement and scirrhous type in stroma.
Prognosis in patients with h-EGF producing tumors was poorer than that in those with h-EGF non-producing tumors, especially in stages II and III.
These results suggest that h-EGF immunoreactivities serves as a biological marker of high malignancy.
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