J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 853KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 89(5): 771-775, 1988

Original article

STUDIES ON TISSUE PO2 AND BIOCHEMICAL ANALYSIS OF THE SKELETAL
MUSCLE OF LEGS WITH CHRONIC ARTERIAL OCCLUSIVE DISEASES

Division of Thoracic Cardiovascular Surgery, Department of Surgery, Kawasaki Medical School, Kurashiki, Japan
*) Second Department of Biochemistry, Kawasaki Medical School, Kurashiki, Japan

Takashi Yamamoto, Takashi Fujiwara, Soroku Dokoh, Hiroshi Inada, Hisao Masaki, Tatsuki Katsumura, Kosuke Ichihara*)

Measurements of maximum tissue PO2 during 100%O2 inhalation (PtO2max) and biochemical analysis of the skeletal muscle were performed in 3 legs without ischemia and 14 legs with chronic arterial occlusive disease requiring amputation.
There were significant good correlations between PtO2max and levels of pH, lactate, enzymes (CPK,LDH, Aldolase) and ATP in the skeletal muscle with ischemia. In regions in which PtO2max was below 10mmHg, ischemic changes in the muscle were considered to be irreversible.
On the contrary, primary wound healing was obtained in regions with 40mmHg or more of PtO2max.
Measurements of the PtO2max of the ischemic muscles provided much useful information concerning the reversibility of muscle ischemia and for decision of the amputation level.

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