J.Jpn. Surg. Soc.. 89(5): 694-702, 1988
Original article
EXPERIMENTAL STUDY ON LIPID METABOLISM AFTER PARTIAL HEPATECTOMY
―WITH REFERENCE TO MITOCHONDRIAL FUNCTION OF REGENERATING LIVER
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First Department of Surgery, Yamagata University School of Medicine, Yamagata, Japan Shigeru Katagiri |
In normal rats, the fat accumulation in regenerating livers was observed, which had a maximal peak at 24 hours after hepatectomy. It could be a result of mobilization of fatty acids from fat tissue accompanied with hyperglucagonemia after hepatectomy. Mitochondrial respiration in regenerating liver increased remarkably. Especially when palmitoylcarnitine was used as a substrate, both the respiratory index and ATP synthesis rate were high until 72 hours after hepatectomy. Mitochondrial carnitine palmitoyltransferase activity was also high. The increase of mitochondrial respiration with palmitoylcarnitine as a substrate was also observed in cirrhotic liver until 72 hours after hepatectomy. These results suggest that mobilization of fatty acids increases after hepatectomy and regenerating liver utilizes fatty acids as a main substrate for hepatic regeneration.
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