J.Jpn. Surg. Soc.. 89(2): 238-244, 1988
Original article
PANCREATIC MICROCIRCULATION IN ACUTE PANCREATITIS OF DOGS
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The First Department of Surgery, Osaka City University Medical School, Osaka, Japan Hideki Nishiwaki, Katsusuke Satake, Ichikun Ko, Kaoru Umeyama |
In acute pancreatitis dogs femoral artery pressure and pulse pressure gradually decreased and pancreatic microflow in basal state temporarily increased immediately after bile injection, however, thereafter continuously decreased during the experiments. Portal flow severely decreased just after onset of acute pancreatitis.
By administration of dopamine femoral artery pressure was maintained during the first 90 minutes of experiments, however, thereafter decreased until the end of experiments. Pancreatic microflow, 56. 1±15.3ml/min/100g in basal level was shown 66.1±13.7 and 60.3±10.3ml/min/100g at 1 and 2 hours, respectively, after bile injection, which were significantly high values as compared with those of non dopamine administration. However those values decreased at 5 hours of both experiments. Portal flow whose basa level was 237±67ml/min was maintained during the first 1 hour however it decreased to 139± 25ml/min at 5 hours.
By administration of pancreatic protease inhibitor femoral artery pressure and pulse pressure, temporarily decreased immediately after bile injection, however, they were maintained thereafter. Pancreatic microflow, 57.1±18.3ml/min/100g in basal level, was maintained during the first 2 hours, however significantly decreased to 27.6±9.7ml/min/100g at 5 hours. Portal flow significantly increased to 442±115ml/min at 2 hours, however, thereafter decreased 219±93ml/min at 5 hours.
These data showed that pancreatic microflow and portal flow decreased in acute pancreatitis, however, they were maintained during the first 2 hours of experiments by administration of dopamine and pancreatic protease inhibitor.
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