J.Jpn. Surg. Soc.. 89(1): 72-83, 1988
Original article
CHANGES OF CARBOHYDRATE METABOLISM AFTER MAJOR RESECTION OF THE PANCREAS, WITH SPECIAL REFERENCE TO THE FIBROTIC PANCREAS CAUSED BY LIGATION OF THE PANCREATIC DUCT
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First Department of Surgery, Mie University School of Medicine, Tsu, Japan Jun Kitamura |
Changes of carbohydrate metabolism and functional and morphological chang es of islet cells in the remnant pancreas were investigated.
1) Immediately after resection of more than 84% of the fibrotic pancreas, diabetes developed, and insulin and glucagon secretion decreased, accompanied with marked degeneration of B, A and D cells in the islets.
2) During the early periods after 63 to 84% pancreatectomy, secretion of both insulin and glucagon decreased, and then showed a tendency to recover, but later the secretion gradually decreased again and so-called Sandmeyer's diabetes developed. The size of the islets and the number of B cells decreased, but the rate of A and D cells in the islets increased relatively in the remnant pancreas.
3) After resection of less than 63% of the fibrotic pancreas, secretion of both insulin and glucagon decreased temporarily with subsequent recovery. Diabetes did not developed. There were no marked morphological changes in the islets, nor significant changes in the distribution of B, A and D cells of the islets in the remnant pancreas.
Diabetes developed after resection of more than 63% of the fibrotic pancreas 4 weeks after ligation of the pancreatic duct, while it developed after resection of more than 74% of the normal pancreas in dogs.
Therefore, with regard to carbohydrate metabolism, resectability of the fibrotic pancreas was about 10% less than that of the normal pancreas in dogs.
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