J.Jpn. Surg. Soc.. 88(8): 947-954, 1987
Original article
STUDIES ON IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH GASTRIC CARCINOMA
―WITH SPECIAL REFERENCE TO ANALYSES WITH MONOCLONAL ANTIBODIES OF T-LYMPHOCYTE SUBSETS AND INTERLEUKIN-2―
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The Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan Masaaki Takeshita, Susumu Ohwada, Seiji Nakamura, Yukio Miyamoto, Masaru Izuo |
The antibody (OKT3, OKT4, OKT8, OKT4/8, Leull, and Leu7) treated cells were analyzed on a Spectrum III automated flow cytometer.
Interleukin-2 was measured by the tritium-labelled thymidine CTLL assay on the supernatants of peripheral blood lymphocytes of gastric cancer patients after 24 hours stimulation with phytohemagglutinin.
The number of OKT3,O KT4 cells and the ratio of OKT4/8 were decreased in patients with advanced gastric carcinoma compared with early gastric carcinoma.
The numbers of Leull and Leu7 cells in patients with stage II and III were in higher levels than those with stage IV.
Interleukin-2 productin was depressed in patients in advanced stage compared with those of early stage.
We concluded that the T-lymphocyte subsets and the interleukin-2 production were useful immunological parameters for gastric ancer patients.
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