J.Jpn. Surg. Soc.. 87(10): 1303-1312, 1986

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Original article

EXPERIMENTAL STUDY ON EFFICACY OF CIMETIDINE AND 16,16-dm PGE₂ TO LIVER REGENERATION IN PREVENTION OF STRESS ULCER AFTER PARTIAL HEPATECTOMY IN THE CIRRHOTIC RAT

Stress ulcer is a common phenomenon after hepatectomy for cirrhotic liver. We examined experimentally the influence of cimetidine and 16,16-dm PGE₂ dosaged as counter-measures against stress ulcer on liver regeneration after partial hepatectomy for cirrhotic liver.
Using cimetidine and 16,16-dm PGE₂, there was a noticeable suppression of the onset of water immersion stress ulcer, and both a decline in the blood flow in the wall of the stomach and a drop in PH in the stomach were inhibited after partial hepatectomy for cirrhotic liver.
The group given 16,16-dm PGE₂ after partial hepatectomy had a higher rate of DNA synthesis as compared with the group which had only partial hepatectomy. No difference was seen between the group given cimetidine and the only partial hepatectomy groups.
The group given indomethacin before partial hepatectomy for cirrhotic liver had a noticeable decrease in mitotic index 30 hours after partial hepatectomy. However, the group given both indomethacin and 16,16-dm pGE₂, showed some recovery of the mitotic index.

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