J.Jpn. Surg. Soc.. 87(10): 1293-1302, 1986

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Original article

ROLE OF BLOOD FLOW IN ACUTE GASTRIC LESION AFTER HEPATECTOMY AND EFFECT OF PROSTAGLANDIN I₂ AND H₂-RECEPTOR ANTAGONIST

In order to investigate the cause of gastric mucosal lesion following hepatectomy, changes of gastric, pancreatic and femoral arterial blood flow were measured in 70% hepatectomized rabbits.
1) Following administration of 0.5μg/kg of GRP, gastric blood flow increased to 120% of the basal level in the controls, but reached to only 107% of the basal level in the hepatectomized rabbits.
2) Following hemorrhage of 10% of the total blood volume seven days after hepatectomy, blood flow decreased to 55% of the basal level in the stomach, 57% in the pancreas and 76% in the femoral artery. Although pancreatic blood flow recovered to 81% of the basal level, gastric blood flow remained Iow, 59% of the basal Ievel, suggesting poor recovery of gastric blood flow as compared to pancreatic blood flow.
3) Administration of PGI₂ and ranitidine in hepatectomized rabbits with hemorrhage conferred a considerable degree of recovery of gastric blood flow in the PGI₂ group (from 56% to 80%) and in the ranitidine group (from 52% to 72%). Thus, disturbance of reaction and poor recovery of gastric blood flow following hemorrhage were indicated as important causes of acute gastric mucosal lesion associated with hepatectomy. Both PGI₂ and ranitidine appeared to be effective for the maintenance of gastric blood flow after hepatectomy.

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