J.Jpn. Surg. Soc.. 87(10): 1275-1283, 1986

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Original article

CLINICAL STUDY OF PROTEIN AND AMINO ACIDS METABOLISM IN SURGICAL INFECTION ーSIGNIFICANCE OF ADMINI STRATION OF BRANCHED CHAIN AMINO ACIDS

Anastomotic leakage and fistula of alimentary tract are accompanied by peritonitis because of exudation of contents in the digestive canal. In order to inquire about metabolism of protein and amino acids in surgical infection, this study was performed by the method of a time related cross-over trial, comparing high branched chain amino acids (BCAA) solution with low BCAA solution. The following results were obtained.
1) When metabolism is physiologically compensated in infection, it was suggested that there appeared to be gluconeogenesis, ureagenesis and a liver disturbance accompanied in the early phase of sepsis.
2) Administration of BCAA leads to an inhibition of muscle protein break down and a promotion of visceral protein synthesis in the case of severe infection.
3) Administration of BCAA enriched amino acids solution have an important therapeutic measure under severe stressed condition and a significant role in medicine.

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